Throughout these years, I have enjoyed the financial support of the National Institutes of Health, U. S. Public Health Service, grants MH-02921, M-5268, 1-K-3-MH-21700, and National Science Foundation GS-300. Finally,I would like to express my gratitude to Eleanor F. Rosenberger, who has been responsible for typing and retyping the manuscript, for a gigantic editorial job and for patient library research. 
Cambridge, Mass.                                                       E.H. L.
 
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